Publications by authors named "R E De Filippo"

Minimally invasive liver surgery has become widely accepted as a safe and effective approach, especially with experienced surgeons. Robotic hepatectomy may offer significant benefits in challenging procedures like caudate lobe resection. The caudate lobe's intricate anatomy and deep-seated location make its resection particularly challenging, with limited reports on minimally invasive techniques.

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Purpose: This study analysed the main artificial intelligence (AI) models for the diagnosis of cholesteatoma on computed tomography (CT), evaluating their performance and comparing them with each other. The increasing application of AI in radiology requires a systematic comparison of available methodologies.

Methods: A systematic literature review was conducted, selecting relevant articles from the main databases.

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Serotonin (5-HT) is crucial for regulating brain functions such as mood, sleep, and cognition. This study presents a comprehensive transcriptomic analysis of 5-HT receptors (Htrs) across ≈4 million cells in the adult mouse brain using single-cell RNA sequencing (scRNA-seq) data from the Allen Institute. We observed differential transcription patterns of all 14 Htr subtypes, revealing diverse prevalence and distribution across cell classes.

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Article Synopsis
  • - Fasting-mimicking diets (FMD), specifically a low-salt version (LS-FMD), were tested in rats with kidney damage and were found to restore normal kidney function and structure by inducing a nephrogenic gene program.
  • - LS-FMD activated pathways that promote cell reprogramming in the kidney, specifically targeting podocytes, which play a critical role in kidney health.
  • - A pilot study in patients with chronic kidney disease showed that FMD cycles improved kidney function and reduced protein levels in urine, indicating potential for further research in treating progressive kidney diseases.
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Introduction: recent studies have shown that around 30 % of men and 20 % of women at the age of 70 have a hearing loss, rates that rise to 55 % and 45 % respectively at the age of 80. Treatment options include hearing aids and cochlear implants. Cochlear implant surgery under local anesthesia (L.

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