A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C-N couplings.

Machine-learning methods have great potential to accelerate the identification of reaction conditions for chemical transformations. A tool that gives substrate-adaptive conditions for palladium (Pd)-catalyzed carbon-nitrogen (C-N) couplings is presented. The design and construction of this tool required the generation of an experimental dataset that explores a diverse network of reactant pairings across a set of reaction conditions.

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

A chromatography-free asymmetric synthesis of GDC-6036 () was achieved via a highly atroposelective Negishi coupling of aminopyridine and quinazoline catalyzed by 0.5 mol % [Pd(cin)Cl] and 1 mol % (,)-Chiraphite to afford the key intermediate ()-. An alkoxylation of ()- with ()--methylprolinol () and a global deprotection generates the penultimate heterobiaryl intermediate .

White Parents' Socialization of Racial Attitudes: A Commentary on Scott et al. (2020).

In the September 2020 issue of , Scott et al. argued that there is insufficient empirical work on White parents' racial-socialization strategies to support generalizations about the topic and, therefore, that journalists' recommendation that White parents discuss race and racism with their children represents a case of speculation without evidence. Although we strongly support Scott et al.

When multiracial individuals are the numerical majority: Children's racial attitudes in the Dominican Republic.

The Dominican Republic is a uniquely valuable context in which to study children's racial stereotyping and prejudice, in part because multiracial individuals comprise the majority of the population and race is viewed largely as a continuous rather than dichotomous construct. In two studies, we use developmental and social theories to ground an exploration of Dominican children's racial biases. In studies 1 ( = 54; ages 6-11) and 2 ( = 122; ages 6-11), children were given measures of racial identity, preference, stereotyping, and/or status.