Publications by authors named "R Dusunsel"
Objectives: Intra-articular corticosteroid injection (IACI) is a safe first-line or adjunct therapy used in any subtype of juvenile idiopathic arthritis (JIA). Limited studies evaluated the effect of IACI on cartilage. Our study aimed to examine the femoral cartilage thickness of patients with JIA who received IACI to the knee joint using ultrasound.
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- The study focuses on urinary tract infections (UTIs) in children and investigates the potential use of soluble Toll-like receptors (sTLR4, sTLR5) and interleukin 8 (IL-8) as biomarkers for diagnosing UTIs.
- It involved 520 children, including those with UTIs, non-UTI infections, and healthy controls, measuring urine and serum levels of the biomarkers before and after treatment.
- Results show that urine sTLR4 levels are higher in UTI patients, with a cut-off level identified to predict UTIs, especially higher in cases of pyelonephritis compared to cystitis, and decreasing post-treatment.
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- The study looked at why doctors requested ANA tests for kids with potential autoimmune diseases and how well those tests worked.
- Out of 3,812 kids tested, about 27% had positive ANA results, with juvenile idiopathic arthritis being the most common diagnosis.
- The study found that the ANA test wasn't very reliable for diagnosing these diseases, so doctors should think carefully before using it.
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- * Common neuropsychiatric symptoms included headaches (50.3%), seizures (38.3%), and acute confusional states (33.6%), with five distinct clusters of symptoms identified based on their clinical and laboratory findings.
- * Key factors associated with increased risk of neurologic issues included positivity for antiphospholipid antibodies, history of plasmapheresis treatment, and higher SLEDAI scores, providing insights for better diagnosis and management.
Background: Methotrexate (MTX) is the first-choice disease-modifying drug in juvenile idiopathic arthritis (JIA) treatment. Methotrexate is metabolized in the liver and can cause liver toxicity and fibrosis with long-term use. Ultrasound shear wave elastography (SWE) is a non-invasive method and can detect liver fibrosis by evaluating the liver elasticity.
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