Publications by authors named "R Dubielzig"
Sebaceous carcinomas of the human ocular adnexa commonly exhibit pagetoid spread, mutations in tumor-suppressor genes, and protooncogene copy number gain. Sebaceous carcinomas are rarely reported in other species, and while the Meibomian gland (MG) represents the most common ocular adnexal structure of the canine eyelid to develop neoplasia, most are clinically and histologically benign. The objective of this study was to compare molecular features of canine MG carcinomas and adenomas.
View Article and Find Full Text PDFIn collaboration with the American College of Veterinary Pathologists.
View Article and Find Full Text PDFThe cellular and genetic mechanisms that coordinate formation of facial sensory structures with surrounding skeletal and soft tissue elements remain poorly understood. Alx1, a homeobox transcription factor, is a key regulator of midfacial morphogenesis. ALX1 mutations in humans are linked to severe congenital anomalies of the facial skeleton (frontonasal dysplasia, FND) with malformation or absence of eyes and orbital contents (micro- and anophthalmia).
View Article and Find Full Text PDFArticle Synopsis
- - The text discusses a novel molecular electronics chip that utilizes single molecules as general-purpose sensors, allowing for ultra-miniaturized electronic circuits.
- - The device features a semiconductor chip with an array of synthetic molecular wires connected to nanoelectrodes, enabling real-time monitoring of molecular interactions at high speeds (1,000 frames per second).
- - It demonstrates the ability to measure single-molecule interactions, such as those involving DNA, antibodies, and enzymes, with exceptional sensitivity and without needing labels, which can enhance various applications in biosensing and diagnostics.
In collaboration with the American College of Veterinary Pathologists.
View Article and Find Full Text PDF