Publications by authors named "R Douglas McKnight"
Article Synopsis
- - Flexor tendon injuries require careful management that considers factors like when to operate, where the injury is located, and how to handle surrounding tissues.
- - Common complications from these injuries include adhesions, tendon rupture, infection, and a high likelihood of needing additional surgeries, especially for zone 2 repairs.
- - Special attention is needed for chronic ruptures, fractures that happen alongside tendon injuries, and cases involving children, with the aim to improve patient outcomes through current treatment concepts.
Background: Scaphoid fractures are less commonly reported in adults older than 50 years. The association between bone density and outcomes following scaphoid fractures has not been explored in this patient population. The second metacarpal cortical percentage (2MCP) has been shown to predict low bone density.
View Article and Find Full Text PDFIntroduction: At UNC, venous thromboembolism (VTE) patients are treated with a heparin nomogram including fixed-dose titration boluses to correct subtherapeutic heparin correlation values (HCVs). The bolus dose often exceeds the recommended loading dose in underweight patients, therefore raising concern for an increased bleeding risk. This evaluation aims to assess the safety of these titration boluses for underweight patients.
View Article and Find Full Text PDFActivation of HER2/ErbB2 coincides with escape from ductal carcinoma in situ (DCIS) premalignancy and disrupts 3D organization of cultured breast-epithelial spheroids. The 3D phenotype is infrequent, however, and mechanisms for its incomplete penetrance have been elusive. Using inducible HER2/ErbB2-EGFR/ErbB1 heterodimers, we match phenotype penetrance to the frequency of co-occurring transcriptomic changes and uncover a reconfiguration in the karyopherin network regulating ErbB nucleocytoplasmic transport.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how intrauterine growth restriction (IUGR) and a high-fat diet (HFD) separately contribute to a higher risk of cardiovascular disease (CVD) and hyperlipidemia, with IUGR being associated with increased blood pressure and vascular issues as early as early life.
- - Adult female rats were used in the study, with groups divided based on their diet during pregnancy and lactation, along with their offspring's weaning diets to determine the long-term effects on cardiovascular health and tissue structure.
- - Results indicated that rats from HFD mothers displayed significant arterial stiffness, signs of potential atherosclerosis, and increased blood lipid levels post-weaning, with IUGR amplifying the negative