Harnessing conformational drivers in drug design.

This review article explores the pivotal role of conformational drivers in the discovery of drug-like molecules and illustrates their significance through real-life examples. Understanding molecular conformation is paramount to drug hunting as it can impact on- and off-target potency, metabolism, permeability, and solubility. Each conformational driver or effector is described and exemplified in a separate section.

Mechanistic analysis by NMR spectroscopy: A users guide.

A 'principles and practice' tutorial-style review of the application of solution-phase NMR in the analysis of the mechanisms of homogeneous organic and organometallic reactions and processes. This review of 345 references summarises why solution-phase NMR spectroscopy is uniquely effective in such studies, allowing non-destructive, quantitative analysis of a wide range of nuclei common to organic and organometallic reactions, providing exquisite structural detail, and using instrumentation that is routinely available in most chemistry research facilities. The review is in two parts.

Synthesis of purines and adenines containing the hexafluoroisopropyl group.

Several new derivatives of adenine, purine, and theophylline containing the (CF)CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane () with the corresponding substrates, resulting in the selective alkylation of one of the nitrogen atoms of the imidazole ring. The reaction proceeds under mild conditions in a polar solvent, giving the alkylated products in 47-78% yield. While for purine and 4- and 5-azabenzimidazole, the reaction led to a mixture of two isomers, the reaction of adenine and the corresponding 2-fluoro derivative was regioselective, resulting in the formation of only one isomer in each case.

Intimate Partner Violence Survivors' Housing Needs and Preferences: A Brief Report.

Intimate partner violence (IPV) victimization contributes to homelessness and housing insecurity for survivors and their children. Despite growing interest in expanding strategies for addressing the housing needs of survivors, there is a dearth of knowledge regarding survivors' preferences and recommendations. To begin to address knowledge gaps, this article reports findings from a qualitative study examining the housing needs of IPV survivors and survivors' preferences and recommendations for addressing their housing needs.