Publications by authors named "R Dongilli"
Background: Noninvasive ventilation (NIV) still has high failure rate when used for de novo acute respiratory failure (ARF). Delirium may impact the outcome, however data regarding its incidence, timing of occurrence and clinical predictors in this subset of patients are scarce.
Methods: Consecutive patients with de novo ARF subjected to NIV were recruited in 10 Italian Respiratory Intensive Care Units (RICUs) and Intensive Care Units (ICUs).
Rationale: Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia.
Methods: In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with COVID-19 pneumonia were randomised to receive 1 g of methylprednisolone intravenously for three consecutive days or placebo in addition to standard dexamethasone.
Article Synopsis
- The "Berlin definition" of ARDS currently excludes patients on high-flow nasal oxygen (HFNO), but there's ongoing debate about expanding the criteria to include them.
- Researchers studied COVID-19 patients using HFNO and noninvasive ventilation (NIV) to compare ARDS severity and 28-day mortality before and after transitioning to invasive mechanical ventilation (IMV).
- The study found that patients who remained on HFNO had significantly lower 28-day mortality rates compared to those who transitioned to IMV, suggesting that including HFNO patients in the ARDS definition could help identify those at earlier stages of the disease with better survival outcomes.