The effect of trospium chloride on oesophageal motility.

Trospium chloride is a muscarinergic antagonist acting on oesophageal smooth muscle and on ganglionic and/or myenteric neurons. The effect of this drug on oesophageal motility was tested in 16 healthy male subjects in a double-blind randomized cross-over examination of trospium chloride or placebo following phentolamine or placebo application. Each subject underwent two separate investigations at least one week apart.

[Abdominal intercostal nerve pain. A contribution to differential diagnosis of acute abdominal pain].

Intercostal nerves and their vascular supply can be impinged in a fascial gap of the m.rectus abdominalis and cause neural pain simulating visceral symptoms. The diagnosis is based on clinical symptoms and proven by histological demonstration of cicatricial impingement of an intercostal nerve.

Efficacy and benefit of mediastinal computed tomography as a selection method for mediastinoscopy.

In 95 consecutive patients with proven or suspected bronchial carcinoma, computed tomographic evaluation of the upper mediastinum for N2 disease was performed prospectively. Patients with positive results underwent mediastinoscopy. Patients with perinodal N2 or N3 disease at mediastinoscopy were not considered candidates for operation.