Publications by authors named "R Doctor"
The insertion/deletion, I/D polymorphism, in the gene encoding Angiotensin Converting Enzyme, ACE is a popular genetic marker for cardiovascular disease, CVD. With alarming rise in diabetes, the risk of CVD among Indian subjects is further enhanced. The present study explored the role of ACE I/D polymorphism, rs4340 as a genetic marker and its association with diabetes.
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- This study aimed to evaluate whether forced-air warming improves immune function in critically ill sepsis patients compared to standard temperature management.
- Conducted in a large academic medical center, it involved mechanically ventilated septic adults who met specific criteria and excluded those with certain immunologic conditions.
- Results showed no significant differences in immune markers (HLA-DR expression and IFN-γ production), but patients receiving the warming intervention had lower 28-day mortality and more days free from the hospital compared to the control group.
Extensive spatial and temporal distribution of high-quality data are essential for understanding regional and global behaviors of the geomagnetic field. We carried out chronological and archaeomagnetic studies at the Angkor-era iron-smelting site of Tonle Bak in Cambodia in Southeast Asia, an area with no data available to date. We recovered high-fidelity full-vector geomagnetic information from the 11th to 14th century for this region, which fill gaps in the global distribution of data and will significantly improve the global models.
View Article and Find Full Text PDFBackground: Fever is common in mechanically ventilated patients and may be uniquely detrimental in those with lung injury because of its injurious effects on pulmonary vascular permeability and alveolar epithelium. We evaluated the association of fever and antipyretic medication with mortality in mechanically ventilated emergency department (ED) patients.
Methods: This is a retrospective cohort study of 1,264 patients requiring mechanical ventilation initiated in the ED with subsequent admission to an intensive care unit.
Intact red blood cells (RBCs) are required for phenotypic analyses. In order to allow separation (time and location) between subject encounter and sample analysis, we developed a research-specific RBC cryopreservation protocol and assessed its impact on data fidelity for key biochemical and physiological assays. RBCs drawn from healthy volunteers were aliquotted for immediate analysis or following glycerol-based cryopreservation, thawing, and deglycerolization.
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