Publications by authors named "R Djaldetti"
Article Synopsis
- The study examines the link between Parkinson's disease (PD) and skin cancer risk factors, looking specifically at actinic keratosis (AK), non-melanoma skin cancer (NMSC), and cutaneous malignant melanoma (CMM) among individuals with and without PD.
- A total of 141 patients with PD and 155 controls were analyzed, revealing that CMM was more prevalent in PD patients, with risk factors like prolonged sun exposure, freckles, and solar lentigines particularly associated with skin tumours in the PD group.
- The research indicates that while certain skin tumour risk factors exist, PD status by itself isn't independently linked to these risks, highlighting the need for regular dermatological
Background: Advanced Parkinson's disease (PD) can be treated with Levodopa-Carbidopa Intestinal Gel (LCIG).
Objective: To compare descriptive data of LCIG treatment in GBA1-PD and LRRK2-PD.
Methods: This multicenter retrospective study compared clinical data obtained from electronic medical records of PD patients treated with LCIG.
Article Synopsis
- Current estimates of genetic variants linked to Parkinson's disease (PD) show limitations and biases across different populations, complicating patient recruitment for clinical trials focused on genetic therapies.
- The Rostock Parkinson's disease (ROPAD) study analyzes data from 12,580 PD patients across 16 countries, revealing that 14.8% had a genetic test positive for PD-related variants, particularly in specific genes like GBA1 and LRRK2.
- Findings indicate higher positivity rates in patients with earlier onset (age ≤ 50) or a positive family history, emphasizing the need for more extensive genetic investigation to improve patient stratification for future clinical trials.
Background: Postural abnormalities involving the trunk are referred to as axial postural abnormalities and can be observed in over 20% of patients with Parkinson's disease (PD) and in atypical parkinsonism. These symptoms are highly disabling and frequently associated with back pain and a worse quality of life in PD. Despite their frequency, little is known about the pathophysiology of these symptoms and scant data are reported about their clinical predictors, making it difficult to prompt prevention strategies.
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- - Multiple system atrophy (MSA) is a severe disease with varying motor and autonomic symptoms, and previous studies have linked certain clinical factors to reduced survival rates.
- - Researchers analyzed 210 MSA patients over 17 years to create a survival risk model using clinical factors like age at symptom onset and early autonomic failure.
- - They developed a nomogram to predict individual survival probabilities over 7 years, which showed good accuracy and could enhance patient counseling and treatment strategies.