Digital Twins in Biomanufacturing.

In recent years process modelling has become an established method which generates digital twins of manufacturing plant operation with the aid of numerically solved process models. This article discusses the benefits of establishing process modelling, in-house or by cooperation, in order to support the workflow from process development, piloting and engineering up to manufacturing. The examples are chosen from the variety of botanicals and biologics manufacturing thus proving the broad applicability from variable feedstock of natural plant extracts of secondary metabolites to fermentation of complex molecules like mAbs, fragments, proteins and peptides.

Process Engineering Accelerating an Economic Industrialization Towards a Bio-Based World.

The transition towards a bio-based world is a challenging undertaking. This perspective paper, from an engineering point of view, aims to provide an overview of existing projects and academic disciplines highlighting the potential benefit of increased interdisciplinary exchanges. Furthermore, the current utilization of biomass to produce biogas is discussed, including an economic assessment, showing the need for new strategies of biomass valorization.

Trends in Upstream and Downstream Process Development for Antibody Manufacturing.

A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for efficient process development.

Liquid chromatography--its development and key role in life science applications.

Liquid chromatographic methods cover the broadest range of applications imaginable today. Nowhere is this more evident and relevant than in the life sciences, where identification of target substances relevant in disease mechanisms is performed down to the femtomole level. On the other hand, purification of therapeutic drugs on a multi-ton scale is performed by process LC.

Portable laser-heating stand for synchrotron applications.

A compact, double-sided laser-heating system for diamond-cell synchrotron applications is described. The optical table, containing laser, spectrometer, and all optics for visual observation and measuring temperatures and pressures has an area of less than 1/2 m(2) and weighs less than 20 kg. All components can be remotely controlled at micron levels with simple dc motors and pneumatic drives.