Publications by authors named "R Dingelmaier-Hovorka"
Chlamydia trachomatis (Ct) is the most common cause for bacterial sexually transmitted infections (STIs) worldwide with a tremendous impact on public health. With the aim to unravel novel targets of the chlamydia life cycle, we screen a compound library and identify 28 agents to significantly reduce Ct growth. The known anti-infective agent pentamidine-one of the top candidates of the screen-shows anti-chlamydia activity in low concentrations by changing the metabolism of host cells impairing chlamydia growth.
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- Skin shows big changes as we age, often due to damage from things like stress and DNA issues.
- Damage to our skin cells can speed up aging and lead to diseases like cancer.
- A protein called PRPF19 may help keep skin cells healthy and slow down aging by making them act younger and helping heal wounds.
People living with HIV (PLWH) are at increased risk for developing skin and mucosal malignancies despite systemic reconstitution of CD4 T cells upon antiretroviral therapy (ART). The underlying mechanism of chronic tissue-related immunodeficiency in HIV is unclear. We found that skin CD4 tissue-resident memory T (Trm) cells were depleted after HIV infection and replenished only upon early ART initiation.
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- Emigration of tissue-resident memory T cells (TRMs) in mouse models is linked to systemic inflammation and is observed in skin TRMs during allogeneic hematopoietic stem cell transplantation (HSCT) in humans.
- Research identified a specific population of circulating skin-derived T cells (cTRMs) in the blood of patients, which share characteristics with skin TRMs and are involved in producing inflammatory cytokines.
- Elevated levels of cTRMs in patients with graft-versus-host disease (GVHD) highlight their potential role in driving inflammation not just in the skin, but also in distant organs, suggesting they could be targeted for therapeutic interventions.
The exact correlation between melanoma and sun-light is still a controversially debated issue. Although natural sunlight contains various ratios of UVA and UVB, most investigators so far focused on the effects of single solar wavebands and neglected possible interactions. Therefore, in this study primary human melanocytes of three donors were simultaneously exposed to physiologic doses of UVA1 and UVB.
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