Fibrous Dysplasia of Sphenoid: A Case Report.

Fibrous dysplasia, a rare benign condition with an uncertain cause, is characterized by substituting normal medullary bone with abnormal and weak fibrous and osseous tissue. This primary bone disorder is non-neoplastic and involves a deficiency in osteoblastic differentiation and maturation, which begins in the bone's mesenchymal precursor. A 20-year-old female attended ENT OPD with complaints of headache for 3 years, A diagnostic nasal endoscopy was done which showed no significant abnormalities, and CT PNS was done which showed Extensive sclerotic bony expansion with a ground glass appearance involving the clivus, right greater wing of sphenoid, pterygoid processes - Likely fibrous dysplasia since she had no other signs or symptoms, she was kept under observation.

Machine learning aided UV absorbance spectroscopy for microbial contamination in cell therapy products.

We demonstrate the feasibility of machine-learning aided UV absorbance spectroscopy for in-process microbial contamination detection during cell therapy product (CTP) manufacturing. This method leverages a one-class support vector machine to analyse the absorbance spectra of cell cultures and predict if a sample is sterile or contaminated. This label-free technique provides a rapid output (< 30 minutes) with minimal sample preparation and volume (< 1 mL).

Operando-informed precatalyst programming towards reliable high-current-density electrolysis.

Electrocatalysts support crucial industrial processes and emerging decarbonization technologies, but their design is hindered by structural and compositional changes during operation, especially at application-relevant current densities. Here we use operando X-ray spectroscopy and modelling to track, and eventually direct, the reconstruction of iron sulfides and oxides for the oxygen evolution reaction. We show that inappropriate activation protocols lead to uncontrollable Fe oxidation and irreversible catalyst degradation, compromising stability and reliability and precluding predictive design.

Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin.

Background: Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction to medication that presents within 72 hours of exposure with erythematous papules and plaques with overlying pustules. The immunopathogenesis and predisposing factors of AGEP are not well characterized.

Objective: To better understand the genetic risk factors and single-cell immunopathogenesis of AGEP, we longitudinally characterized a patient with recurrent AGEP after an initial episode triggered by vancomycin.