Publications by authors named "R Diaz-Simon"

Article Synopsis
  • Influenza virus infection can lead to severe outcomes like respiratory failure and death, but the mechanisms behind these effects are not well understood.
  • A study was conducted on hospitalized patients during the 2017/18 and 2018/19 flu seasons, measuring immune markers and other relevant factors to assess their impact on disease progression.
  • Findings revealed that patients with poor outcomes had lower levels of Apolipoprotein-H and higher levels of inflammatory markers, indicating that a dysregulated immune response contributes to worse prognoses in influenza cases.
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Introduction: SARS-CoV-2 is a highly contagious virus, and despite professionals' best efforts, nosocomial COVID-19 (NC) infections have been reported. This work aimed to describe differences in symptoms and outcomes between patients with NC and community-acquired COVID-19 (CAC) and to identify risk factors for severe outcomes among NC patients.

Methods: This is a nationwide, retrospective, multicenter, observational study that analyzed patients hospitalized with confirmed COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry) from March 1, 2020, to April 30, 2021.

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Objectives: Non-functioning gastrin-producing neuroendocrine neoplasms (NEN) of the duodenum are rare gastrointestinal tumors without a clinical syndrome due to gastrin production. Their incidence has significantly increased as an incidental finding during endoscopic studies. The aim of this study was to describe the characteristics and prognostic factors of this emergent and infrequent neoplasm.

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NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor in the outcome of the disease. This work has studied NK degranulation and innate immunological profiles and functionalities in COVID-19 patients and its association with the severity of the disease. A prospective observational study with 99 COVID-19 patients was conducted.

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