Cost-Effectiveness Of Midostaurin In The Treatment Of Acute Myeloid Leukemia With The FLT3 Mutation In Spain.

Purpose: The addition of midostaurin to standard chemotherapy (cytarabine and daunorubicin) has shown significant improvements in the survival of patients with acute myeloid leukemia with the FLT3 mutation (FLT3-AML). The objective of this study was to determine whether this intervention would be cost-effective in Spain.

Methods: A partitioned survival model with five health states was developed (diagnosis and induction, complete remission, no complete remission, transplantation and death).

Physical restraint in the ICU: does it prevent device removal?

Background: Physical restraint is frequently used in the intensive care setting but little is known regarding its clinical scenario and effectiveness in preventing adverse events (AEs), defined as device removal.

Methods: We carried out a prospective observational study in three Intensive Care Units on 120 adult high-risk patients. The effectiveness of physical restraint was evaluated using the propensity score methodology in order to obtain comparable groups.

Absence of correlation between the spontaneously hypertensive rat's exaggerated preference for sweet and alcohol drinking solutions.

We tested the hypothesis that the exaggerated preference of the spontaneously hypertensive rat of the Okamoto strain (SHR) for alcohol-containing drinking solutions is due to its exaggerated preference for the purported sweet subtaste of alcohol. To do, this we examined in SHR (and Brown Norway (BN) controls) whether preferences for alcohol and glucose-drinking solutions were correlated. No significant correlation was found between alcohol and glucose preference in either the SHR or BN.

Myocardial gene expression associated with genetic cardiac hypertrophy in the absence of hypertension.

The hypertrophic heart rat (HHR) was derived from the spontaneously hypertensive rat of the Okamoto strain and develops cardiac hypertrophy in the absence of hypertension. The genetic basis of this hypertrophy is unknown. Therefore, we compared gene expression profiles in the left ventricular myocardium of young (8-10 weeks of age) and old (38-50 weeks) HHR with rats from an age-matched control strain, the normal heart rat (NHR).

Osmoregulatory fluid intake but not hypovolemic thirst is intact in mice lacking angiotensin.

Water intakes in response to hypertonic, hypovolemic, and dehydrational stimuli were investigated in mice lacking angiotensin II as a result of deletion of the angiotensinogen gene (Agt-/- mice), and in C57BL6 wild-type (WT) mice. Baseline daily water intake in Agt-/- mice was approximately threefold that of WT mice because of a renal developmental disorder of the urinary concentrating mechanisms in Agt-/- mice. Intraperitoneal injection of hypertonic saline (0.