Decoding KRAS mutation in non-small cell lung cancer patients receiving immunotherapy: A retrospective institutional comparison and literature review.

Introduction: KRAS mutation the most common molecular alteration in advanced non-small cell lung cancer (NSCLC) and is associated with an unfavourable prognosis, largely due to the lack of targeted therapeutic options for the majority of the KRAS mutated isoforms. The landscape of NSCLC treatment has expanded with the introduction of immune checkpoint inhibitors (ICIs). Nonetheless, data regarding the efficacy of ICI in NSCLC patients harbouring KRAS mutations are conflicting.

Microplastic pollution in marine sediments of the Antarctic coastal environment of Potter Cove and nearby areas (25 de Mayo/King George Island, South Shetlands).

Plastic contamination in the Southern Ocean is a growing issue. This study provides the first comprehensive analysis of marine microplastics (MPs) (0.1-5 mm) in surface sediments in Potter Cove and nearby areas around Argentina's Carlini station (25 de Mayo/King George Island, South Shetlands).

From Traditionally Extensive to Sustainably Intensive: A Review on the Path to a Sustainable and Inclusive Beef Farming in Brazil.

Brazil is the second largest beef producer and a leading exporter, contributing to some 3000 t CWE in global markets (27.7% of market share). The sector has experienced substantial development, but yields remain far below potential, and there are growing concerns regarding land use change and greenhouse gas emissions.

Like noodles in a soup: Anthropogenic microfibers are being ingested by juvenile fish in nursery grounds of the Southwestern Atlantic Ocean.

The balance between marine health and ecosystem sustainability confronts a pressing threat from anthropogenic pollution. Estuaries are particularly susceptible to contamination, notably by anthropogenic microfibers originated from daily human activities in land and in fishing practices. This study examines the impact of anthropogenic microfibers on the whitemouth croaker in an estuarine environment of the Southwestern Atlantic Ocean during cold and warm seasons.