Basal cell carcinoma (BCC) is the most prevalent form of skin cancer; it is slow-growing and locally invasive with an extremely low likelihood of metastasis. The activation of the Hedgehog (HH) signaling pathway is implicated in nearly all cases, with ultraviolet radiation being the primary risk factor. While BCC typically occurs in areas of chronic sun exposure, it can rarely develop in non-sun-exposed areas, as demonstrated by our case of a 68-year-old Indian woman presenting with a BCC lesion on her left hip.
View Article and Find Full Text PDFObjective: Our study aimed to (1) examine the effect of adjunctive high-definition transcranial direct current stimulation (HD-tDCS) in craving and withdrawal among patients with opioid use disorder on buprenorphine-naloxone, and (2) examine effect of HD-tDCS changes in glutamate-glutamine and γ-aminobutyric acid (GABA) at the left dorsolateral prefrontal cortex (DLPFC) among patients with opioid use disorder on buprenorphine-naloxone.
Methods: This was a pilot randomized double-blind, sham-controlled parallel-group study. A total of 28 patients on buprenorphine-naloxone (6/1.
Objective: In schizophrenia, negative symptoms account for a substantial amount of the comorbidity resulting in poor performance in social interaction, interpersonal relationships, economic functioning, and recreational activities. Research has implicated hypofrontality in the pathogenesis of negative symptoms of schizophrenia. Conventional transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex has attracted significant interest as an add-on treatment for negative symptoms in schizophrenia.
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