Prevalence of Asthma and Its Associated Risk Factors Among Children Aged 5-10 Years in a Rural Area of Coimbatore: A Community-Based Cross-Sectional Study.

Introduction Asthma is one of the serious health problems among children, accounting for a major proportion of lost school days due to absenteeism, decreased academic performances, and lesser social interactions. It can impair a child's activities like playing sports and also their sleeping pattern with frequent school absenteeism. In South India, only a few school-based studies to determine the prevalence of asthma have been carried out, and even fewer studies are done in community settings in rural areas of Tamil Nadu.

Contrasting the effect of hinge region insertions and non-active site mutations on HIV protease-inhibitor interactions: Insights from altered flap dynamics.

HIV-1 protease (PR) enzyme is a viable antiretroviral drug target due to its crucial role in HIV maturation. Over many decades, the HIV-1 PR enzyme has exhibited mutations brought on by drug pressure and error-prone nature of HIV-1 reverse transcriptase. Non-active site mutations have played a pivotal role in drug resistance; however, their mechanism of action has not been fully elucidated.

Multidimensionality in merit attitudes: The role of hard work, skills, and social connections in Europe.

Attitudinal scholarship on values related to merit often identifies three key dimensions that include: attitudes towards hard work, attitudes towards skill, and attitudes towards social connections. In this paper, we examine how individuals evaluate the importance of these three dimensions simultaneously and from a multidimensional framework. We apply Latent Class Analysis (LCAs) on data from round 9 of the European Social Survey (ESS).

Introns with branchpoint-distant 3' splice sites: Splicing mechanism and regulatory roles.

The two transesterification reactions of pre-mRNA splicing require highly complex yet well-controlled rearrangements of small nuclear RNAs and proteins (snRNP) in the spliceosome. The efficiency and accuracy of these reactions are critical for gene expression, as almost all human genes pass through pre-mRNA splicing. Key parameters that determine the splicing outcome are the length of the intron, the strengths of its splicing signals and gaps between them, and the presence of splicing controlling elements.

60 Years of Betaine 30─From Solvatochromic Discovery to Future Frontiers.

Betaine-30 (B30) was reported by Karl Dimroth and Christian Reichardt et al. in 1963 as a solvatochromic probe that can be easily synthesized, shows good solubility, and remains stable in various organic solvents and solutions. Its strongly negatively solvatochromic behavior arises from differential solvation between its electronic ground and excited states, making it a valuable tool for assessing solvent polarity using the (30) polarity scale, also devised by Dimroth and Reichardt.