Publications by authors named "R Dechend"
Leucine-rich repeat-containing G protein-coupled receptors 5/4 (LGR5/LGR4) are critical stem cell markers in epithelial tissues including intestine. They agonise wingless-related integration site (WNT) signalling. Until now, LGR5/LGR4 were uncharacterised in placenta, where analogous functions may exist.
View Article and Find Full Text PDFBackground: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step toward protecting mother and child from this syndrome and increased risk of cardiovascular disease later in life. However, effective early predictive tests and therapies for preeclampsia are scarce.
View Article and Find Full Text PDFArticle Synopsis
- Microvascular imaging is becoming crucial for diagnosing and treating various diseases, highlighting the need to study how different organs communicate through their vascular systems.
- A new perfusion protocol has been developed to effectively deliver a contrast agent to the micro-vessels of multiple organs in the same animal model, ensuring consistency and repeatability in the process.
- The research also focuses on optimizing image acquisition by balancing shorter scanning times with high spatial resolution, resulting in a robust protocol for investigating vascular health and disease across different organs.
Article Synopsis
- * Complications during pregnancy, like hypertensive disorders, are linked to a higher risk of CVD in women, but systematic follow-up care is often lacking after these issues.
- * Implementing early risk factor identification and prevention strategies postpartum could significantly enhance women's cardiovascular health and reduce the incidence of CVD in society.