Publications by authors named "R De Simone"
The extracellular matrix (ECM) plays a central role in the structural integrity and functionality of the cardiovascular system. Moreover, the ECM is involved in atherosclerotic plaque formation and stability. In fact, ECM remodeling affects plaque stability, cellular migration, and inflammatory responses.
View Article and Find Full Text PDFPhysical activity highly impacts the neuroendocrine system and hormonal secretion. Numerous variables, both those related to the individual, including genetics, age, sex, biological rhythms, nutritional status, level of training, intake of drugs or supplements, and previous or current pathologies, and those related to the physical activity in terms of type, intensity, and duration of exercise, or environmental conditions can shape the hormonal response to physical exercise. The aim of this review is to provide an overview of the effects of physical exercise on hormonal levels in the human body, focusing on changes in concentrations of hormones such as cortisol, testosterone, and insulin in response to different types and intensities of physical activity.
View Article and Find Full Text PDFBackground: this study was performed under the umbrella of the Health Extended Alliance for Innovative Therapies, Advanced Lab Research, and Integrated Approaches of Precision Medicine (HEAL ITALIA) partnership and funded under the National Recovery and Resilience Plan, Mission 4 Component 2 Investment 1.3, and by the European Union.
Objectives: the overall objective of the HEAL project is to identify innovative and effective therapeutic approaches to reduce disease burden.
Article Synopsis
- MOH (Medication Overuse Headache) can occur from excessive pain relief medication use, but anti-CGRP monoclonal antibodies like galcanezumab have shown promise as preventive treatments.
- A study involving 75 patients compared the effectiveness and safety of galcanezumab alone, galcanezumab with prednisone, and prednisone alone over a 3-month period.
- All treatments reduced headache frequency significantly, but the galcanezumab combined with prednisone resulted in the greatest reduction; however, prednisone had more side effects, suggesting its use should be limited to cases unresponsive to other treatments.
Article Synopsis
- Genome Resources Banks (GRBs) are essential for collecting and managing genetic material to protect biodiversity for research and conservation purposes.
- They help in species preservation and genetic management, particularly for endangered animals, by storing genetic information securely to counteract population risks.
- The article discusses the ethical concerns around wildlife biobanking practices and suggests using a tool called ETHAS to ensure these procedures maintain high ethical standards throughout their development and operation.