Avelumab Maintenance Therapy in Advanced Urothelial Carcinoma: Implications of Timing and Treatment Sequencing.

Background: Platinum-based chemotherapy (PBC) followed by avelumab maintenance is a treatment option for patients with advanced urothelial carcinoma (aUC) patients. However, the optimal treatment sequencing in the era of antibody-drug conjugates (ADCs) is yet to be determined. Recent studies suggest that the timing of immune checkpoint inhibitor (ICI) administration may impact patient outcomes, with a potential benefit from morning infusions.

Ultra-confined plasmons reveal moiré patterns in a twisted bilayer graphene-talc heterostructure.

This work investigates the plasmonic properties of a twisted bilayer graphene (TBG) and talc heterostructure. Talc, a naturally occurring phyllosilicate, promotes p-type charging of graphene, supporting high charge mobility and strong interaction between graphene plasmons and talc's phonon polaritons. This interaction results in the formation of surface plasmon-phonon polariton (SP) modes, which are detected using infrared scattering-type scanning near-field optical microscopy (IR s-SNOM) at room temperature.

Bayesian uncertainty estimation of adsorption closure models in the computational simulation of contaminant transport.

Identifying sources and understanding the evolution of the spread of contaminants in aquifers is critical and often results in a high-dimensional inverse problem. Computer contaminant transport models are developed by combining physical principles and phenomenological closure equations. However, such models suffer from considerable conceptual uncertainties, mainly due to using phenomenological closures to describe the contaminant adsorption in the media.

Development and Characterization of Silibinin-Loaded Nanoemulsions: A Promising Mucoadhesive Platform for Enhanced Mucosal Drug Delivery.

Silibinin (SLB), a flavonoid derived from milk thistle, exhibits promising therapeutic properties but faces significant clinical limitations due to poor solubility and bioavailability. This study focuses on the development and characterization of SLB-loaded nanoemulsions designed for mucosal delivery. Nanoemulsions were prepared using the spontaneous emulsification method, guided by pseudoternary phase diagrams to determine selected component ratios.

Nilotinib attenuates vascular pathology in experimental cerebral malaria.

Cerebral malaria (CM), a life-threatening complication of Plasmodium falciparum infection, is characterized by the sequestration of infected erythrocytes in the brain microvasculature. Our study investigated the potential of repurposing anti-cancer BCR-ABL drugs, also known to be effective against P. falciparum blood-stage parasites, for mitigating inflammation and blood-brain barrier breakdown in CM.