Publications by authors named "R Dario Falcone"
Article Synopsis
- A multicenter study involving 13 pediatric trauma centers examined the effects of a standardized non-operative management (NOM) approach for children with blunt traumatic pancreatic laceration and ductal injury between 2018-2022.
- Results showed that most patients recovered quickly with a low-fat diet starting after a median of 4 days, and hospital stays averaging 8 days, while complications like cyst development were significantly reduced compared to a historical variable management cohort.
- The findings suggest that using a consistent NOM protocol can improve patient outcomes and that pancreatic ascites at presentation might indicate a higher risk of developing pseudocysts in these cases.
Article Synopsis
- When patients with metastatic melanoma do not respond to PD-1 inhibitors, ipilimumab may be a viable second-line treatment option in the absence of clinical trials.
- A study of 44 patients who received ipilimumab showed significant differences in overall survival based on genetic mutations (BRAF, NRAS) and the presence of brain metastases, with wildtype patients having the best survival rate.
- The findings suggest that ipilimumab remains an effective therapy especially for those without brain metastases, highlighting the importance of genetic profile in treatment outcome.
Article Synopsis
- Immunotherapy using anti-PD-1 antibodies has improved outcomes for advanced melanoma patients, but resistance to treatment is common.
- This study analyzed the efficacy and safety of a weekly carboplatin plus paclitaxel (wCP) chemotherapy regimen in 30 patients who previously underwent anti-PD-1 treatment.
- Key findings showed a median progression-free survival of 3.25 months and overall survival of 7.69 months, with notable factors influencing outcomes including LDH levels and tumor characteristics.
In this study, we determined the temperature-dependent viscosities, glass transition temperatures, and fragilities of tetraalkylphosphonium docusate ionic liquids (ILs) and their equimolar mixtures with alkanes to elucidate the effects of the alkyl groups on the phosphonium cation. The target ILs were the docusate salts with tributylheptylphosphonium ([P][doc]), tributyltetradecylphosphonium ([P][doc]), butyltrihexylphosphonium ([P][doc]), trihexylheptylphosphonium ([P][doc]), and trihexyltetradecylphosphonium cations ([P][doc]). The comparable IL/alkane mixtures were equimolar mixtures of IL and alkane with the same carbon numbers of the target ILs: [P][doc]/hexane to [P][doc]; [P][doc]/heptane to [P][doc]; [P][doc]/hexane to [P][doc]; [P][doc]/decane to [P][doc]; and [P][doc]/heptane to [P][doc].
View Article and Find Full Text PDFBackground: Stage III surgically resected melanoma is a disease at high risk of recurrence. Immune checkpoint inhibitors (ICIs) and the target therapy with BRAF and MEK inhibitors significantly changed the outcome of patients with metastatic melanoma and several studies have also shown their benefit in the adjuvant setting for the delay of recurrence in stage III melanoma patients. Hyperprogression disease was observed as a possible adverse response to immunotherapy in the metastatic setting, suggesting that some patients could face additional risk of progression with ICIs, although no consensus was found for the correct definition of this event.
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