A Novel Dipterocarpol Derivative That Targets Alpha-Glucosidase and NLRP3 Inflammasome Activity for Treatment of Diabetes Mellitus.

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, chronic inflammation, impaired insulin secretion, and/or peripheral insulin resistance. Current α-glucosidase inhibitors approved for clinical use exhibit limited efficacy compared to other glucose-lowering agents. In this study, a series of mono- and bis-benzylidene derivatives were synthesized via aldol condensation of 3-oxo-dammarane triterpenoids with terephthalic aldehyde.

Study of the Spectral Characteristics of Crops of Winter Wheat Varieties Infected with Pathogens of Leaf Diseases.

Studying the influence of the host plant genotype on the spectral reflectance of crops infected by a pathogen is one of the key directions in the development of precision methods for monitoring the phytosanitary state of wheat agrocenoses. The purpose of this research was to study the influence of varietal factors and disease development on the spectral characteristics of winter wheat varieties of different susceptibility to diseases during the growing seasons of 2021, 2022 and 2023. The studied winter wheat crops were represented by three varieties differing in susceptibility to phytopathogens: Grom, Svarog and Bezostaya 100.

Development of Methods for Remote Monitoring of Leaf Diseases in Wheat Agrocenoses.

The development of remote methods for diagnosing the state of crops using spectral equipment for remote sensing of the Earth and original monitoring tools is the most promising solution to the problem of monitoring diseases of wheat agrocenoses. A research site was created on the experimental field of the Federal Research Center of Biological Plant Protection. Within the experimental field with a total area of 1 ha, test plots were allocated to create an artificial infectious background, and the corresponding control plots were treated with fungicides.

Spore-Trapping Device: An Efficient Tool to Manage Fungal Diseases in Winter Wheat Crops.

Leaf airborne diseases cause major shortfalls in agricultural crops. The introduction of technical means can significantly improve early-warning systems for plant diseases as well as provide timely and accurate forecasts. In this paper, we aim to evaluate the possibilities of detecting a phytopathogenic infection using a spore-catching device developed at the Federal Research Center of Biological Plant Protection (FRCBPP) on winter wheat varieties of different levels of susceptibility to major economically important leaf diseases, taking into account climatic conditions.

[EOSINOPHILIC CATION PROTEIN AS A SENSITIVE BIOMARKER OF EOSINOPHILIC INFLAMMATION AND A PREDICTOR OF SEVERE COPD].

It has been established that the eosinophilic phenotype of COPD is separate phenotype of the disease. The results of some studies demonstrate the possibility that may presence a phenotype with an increased level of eosinophil activity. To study the relationship between the blood ECP level and the characteristics of the course of COPD, we examined 161 patients with COPD aged from 40 to 70 years old, smoking index> 10 pack-years, no history of atopy, total blood Ig E <100 IU / ml.