Publications by authors named "R Dan Rudic"
Article Synopsis
- Ischemic stroke can lead to severe disability and death, and researchers are investigating how the timing of a stroke impacts its severity, particularly focusing on the circadian clock protein Rev-Erbα.
- A study found that administering SR9009, a Rev-Erbα agonist, significantly reduced neuroinflammation and infarct size in mice when treated at specific times (ZT06 - during sleep) but not at other times (ZT18 - during wakefulness).
- The results suggest that SR9009 alters immune responses and may offer therapeutic benefits for stroke treatment, emphasizing the importance of timing in administering interventions.
Introduction: The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regulate vascular homeostatic responses, including vasomotor function, vascular wall morphology, and formation of new blood vessels. The role of vascular ADAM17 in neurodegenerative diseases remains poorly understood.
View Article and Find Full Text PDFIn this study a manganese-enhanced magnetic resonance imaging (MEMRI) method was developed for mice for measuring axonal transport (AXT) rates in real time in olfactory receptor neurons, which project from the olfactory epithelium to the olfactory neuronal layer of the olfactory bulb. Using this MEMRI method, two major experiments were conducted: 1) an evaluation of the effects of age on AXT rates and 2) an evaluation of the brain-penetrant, microtubule-stabilizing agent, Epothilone D for effect on AXT rates in aged mice. In these studies, we improved upon previous MEMRI approaches to develop a method where real-time measurements (32 time points) of AXT rates in mice can be determined over a single (approximately 100 min) scanning session.
View Article and Find Full Text PDFArticle Synopsis
- Blood flow and mechanical forces lead to changes in blood vessel structure, and wall shear stress (WSS) is crucial for how blood vessels sense these forces.
- This study investigates the role of ADAM17, a protein that may impair WSS mechanosensing, contributing to abnormal blood vessel changes in aging.
- Findings show that increased ADAM17 in older mice leads to harmful alterations in blood vessel structure, and manipulating its activity can restore normal sensing abilities both in cells and aged blood vessels.