An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive.

Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2). This activation, triggered by ataxia-telangiectasia mutated (ATM) kinase, leads to dopaminergic neuron loss and α-synuclein aggregation, a critical pathophysiological aspect of Parkinson's disease (PD). To halt PD progression, pharmacological inhibition of c-Abl kinase is essential.

Unmasking the Environmental Costs of In-Person General Surgery Residency Interviews.

Objective: As COVID-19 restrictions are eased, there has been a lively debate on whether residency recruitment interviews should be held virtually or in-person. However, environmental impact has rarely been a focus of this debate and only by inference from limited survey data. In this study, we aimed to estimate the carbon emissions generated from air-travel versus in-person interviews in the general surgery residency recruitment.

Photovoltaic module dataset for automated fault detection and analysis in large photovoltaic systems using photovoltaic module fault detection.

Solar energy has become the fastest growing renewable and alternative source of energy. However, there is little or no open-source datasets to advance research knowledge in photovoltaic related systems. The work presented in this article is a step towards deriving Photo-Voltaic Module Dataset (PVMD) of thermal images and ensuring they are publicly available.

Nephrocalcinosis tendency does not worsen under burosumab treatment for X-linked hypophosphatemic rickets: a multicenter pediatric study.

Background: X-linked hypophosphatemic rickets (XLH) is associated with uninhibited FGF23 activity, which leads to phosphaturia, hypophosphatemia and depressed active vitamin D (1,25OH2D) levels. Conventional treatment with phosphate supplements and vitamin D analogs may lead to hypercalciuria (HC), nephrocalcinosis (NC) and hyperparathyroidism. We investigated the effects of burosumab treatment, an anti-FGF23 monoclonal antibody recently approved for XLH, on these complications.