Publications by authors named "R Dahn"
Article Synopsis
- An unprecedented outbreak of highly pathogenic H5N1 avian influenza (HPAI H5N1) affected bovine herds in the USA in spring 2024, leading to infections in other animals and potential spillover to humans.
- Researchers isolated HPAI H5N1 virus from infected cow milk and studied its impact on mice and ferrets, finding that it spread throughout these animals, including to mammary glands, similar to previous strains.
- Although the bovine H5N1 virus showed some ability to bind to human respiratory tissues and transmit minimally among ferrets, it exhibited features that raise concerns about potential infection and spread in mammals.
Background: In 2022 and 2023, novel reassortant H3N8 influenza viruses infected three people, marking the first human infections with viruses of this subtype.
Methods: Here, we generated one of these viruses (A/Henan/4-10CNIC/2022; hereafter called A/Henan/2022 virus) by using reverse genetics and characterized it.
Findings: In intranasally infected mice, reverse genetics-generated A/Henan/2022 virus caused weight loss in all five animals (one of which had to be euthanized) and replicated efficiently in the respiratory tract.
Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is released post-abscission inside large extracellular vesicles called MB remnants (MBRs). Recent evidence suggests that MBRs can modulate cell proliferation and cell fate decisions. Here, we demonstrate that the MB matrix is the site of ribonucleoprotein assembly and is enriched in mRNAs that encode proteins involved in cell fate, oncogenesis, and pluripotency, which we are calling the MB granule.
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