Publications by authors named "R DELAGE"

Introduction: The increasing resistance of Helicobacter pylori to clarithromycin leads to an ongoing adaptation of empirical first-line treatment for H. pylori infections.

Patients And Methods: Prospective study (2022-2023) of 364 patients with no previous treatment for H.

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Complex network approaches have been emerging as an analysis tool for dynamical systems. Different reconstruction methods from time series have been shown to reveal complicated behaviors that can be quantified from the network's topology. Directed recurrence networks have recently been suggested as one such method, complementing the already successful recurrence networks and expanding the applications of recurrence analysis.

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Mantle cell lymphoma (MCL) is a challenging B-cell non-Hodgkin lymphoma with a poor prognosis and frequent relapses. While treatment advancements such as rituximab and Bruton tyrosine kinase inhibitors (BTKi) like ibrutinib have improved outcomes, novel treatments are continually sought. Zanubrutinib, a second-generation BTKi, promises reduced side effects due to its high selectivity and reduced off-target inhibition.

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Infections are a significant cause of morbidity and mortality in myelodysplastic syndrome (MDS). Precise estimates of infection frequency and severity with modern therapies are uncertain. We conducted a retrospective analysis of a prospective cohort enrolled in a Canadian MDS registry and characterized the frequency and severity of infectious complications.

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Article Synopsis
  • Myelodysplastic syndromes (MDSs) treatment aims to improve patients' quality of life (QOL), especially concerning issues such as anemia and transfusion dependence.
  • A study involving 1120 MDS patients revealed that those who maintained transfusion independence (TI) had better overall survival (OS) and QOL compared to those remaining transfusion dependent (TD), while those switching between these statuses had intermediate results.
  • Specifically, patients who transitioned from TD to TI experienced improved QOL, while those moving to TD reported declines in their global QOL, especially in areas like fatigue and daily functioning.
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