Publications by authors named "R D Wegner"
Background: Non-small cell lung cancer (NSCLC) patients often develop brain metastases (BMs), complicating management. We have shown that increasing frailty is associated with decreased overall survival (OS) and central nervous system progression free survival (PFS) for patients undergoing stereotactic radiosurgery (SRS) to BMs. Leveraging the International Radiosurgery Research Foundation, we sought to expand upon these findings, in NSCLC specifically.
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- - Small cell lung cancer (SCLC) often leads to brain metastases, traditionally treated with whole brain radiation therapy (WBRT), but recent approaches focus on stereotactic radiosurgery (SRS) while avoiding the hippocampus.
- - A study analyzed 46 SCLC patients who received SRS for brain metastases, revealing a median overall survival of 13 months and high local control rates (95% at 12 months).
- - Factors such as age, immunotherapy, and number of metastases did not significantly predict survival or local failure; however, 38% experienced distant brain failure within 6 months.
Purpose: Sarcomas metastasizing to the spine are a rare entity. Ideally an En-bloc resection is necessary to achieve durable local control (LC) rates. However, anatomical constraints often limit the degree of tumor resection.
View Article and Find Full Text PDFPurpose: Meningiomas are the most frequent primary intracranial malignancy. While surgical resection can confer long term tumor control, stereotactic radiosurgery (SRS) is often used for small, asymptomatic tumors in the adjuvant setting. Frailty has been associated with increased rates of peri-operative morbidity but has yet to be defined in the setting of SRS for meningiomas.
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