Publications by authors named "R D Treede"

Objective: After over 25 years of developing clinical practice guidelines, the Association of the Scientific Medical Societies in Germany (AWMF) held a symposium to discuss the following topics in order to improve the way evidence is implemented in the delivery of care: expansion of the data pool for guideline development, the regulatory policy framework for this expansion, the transfer of clinical practice guideline statements to medical practice, the associated opportunities and risks resulting from the European legislation.

Methods: The AWMF held its Berlin Forum on 27 April 2022 where experts from scientific medical societies and national institutions in the healthcare sector reported their experiences and perceptions on the topics mentioned. Three writing groups compiled the key statements from these contributions to and discussions made at the Berlin Forum into a position paper.

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Article Synopsis
  • * A consensus meeting in March 2024, attended by 28 experts and stakeholders, aimed to standardize research protocols for studying neuropathic pain using human peripheral tissues.
  • * The meeting resulted in agreed-upon guidelines for phenotyping, laboratory protocols, statistical design, and data sharing to improve consistency in research and enhance understanding of neuropathic pain.
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Although the effect of early childhood stress on central nervous pain processing is well known, studies on the association of prematurity and chronic pain are scarce. This study used data from a single-centre retrospective cohort study followed by a prospective clinical examination and pain assessment. The study was based on data from the local birth registry.

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Article Synopsis
  • - The term "nociplastic pain" describes pain that arises from a sensitized nociceptive system, yet cannot be classified as nociceptive or neuropathic, leading researchers to evaluate a new grading system for distinguishing chronic pain types.
  • - The study involved 81 patients with conditions like fibromyalgia, complex regional pain syndrome, osteoarthritis, and peripheral nerve injury, using various methods to classify their pain as nociplastic; results showed that most chronic primary pain was widespread and not due to clear nociceptive or neuropathic mechanisms.
  • - Despite the grading system having good specificity (93%) when identifying pain types, its sensitivity was low (60%) and inadequate for screening, indicating a need for improvements,
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