Mortality prediction after major surgery in a mixed population through machine learning: a multi-objective symbolic regression approach.

Introduction: Understanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression.

Heightened innate immune state induced by viral vector leads to enhanced response to challenge and prolongs malaria vaccine protection.

Cytomegalovirus is a promising vaccine vector; however, mechanisms promoting CD4 T cell responses to challenge, by CMV as a vector, are unknown. The ability of MCMV to prolong immunity generated by short-lived malaria vaccine was tested. MCMV provided non-specific protection to challenge with and increased interleukin-12 (IL-12) and CD8α dendritic cell (DC) numbers through prolonged MCMV-dependent interferon gamma (IFN-γ) production.

What participants are told about receiving trial results when they consent to participate in a trial.

In a 2022 consultation, the UK public highlighted the need to disseminate trial results to participants. We assess whether the information provided to trial participants in publicly available participant information sheets (PISs) of trials conducted in the UK is helpful for future trials. This cross-sectional study is based on a search conducted on 18 August 2023 on ClinicalTrials.

The effect of swearing on error-related negativity as an indicator for state disinhibition.

Swearing has been linked to increased strength performance, and state disinhibition may be the mechanism linking swearing and strength. Error-related negativity (ERN) is a neural signal associated with response monitoring. Its reduction has been proposed as neural marker for state disinhibition, and therefore, we predicted that swearing would lead to a decreased ERN compared with neutral word repetition, indicating state disinhibition.

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.

SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in tissue damage. Here we show that the host E3-ubiquitin ligase TRIM7 acts as an inhibitor of apoptosis and SARS-CoV-2 replication via ubiquitination of the viral membrane (M) protein.