Publications by authors named "R D Petry"
Graphene oxide (GO) undergoes multiple transformations when introduced to biological and environmental media. GO surface favors the adsorption of biomolecules through different types of interaction mechanisms, modulating the biological effects of the material. In this study, we investigated the interaction of GO with tannic acid (TA) and its consequences for GO toxicity.
View Article and Find Full Text PDFIn this case, a woman in her 80s presented to the emergency department with signs and symptoms of acute pancreatitis that began after starting a course of doxycycline. Common aetiologies of acute pancreatitis, including alcohol use, gallstones and hypertriglyceridaemia were ruled out. Less common aetiologies, including recent Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure, hypercalcaemia, malignancy, infection and trauma, were also ruled out, making drug-induced acute pancreatitis the most likely aetiology.
View Article and Find Full Text PDFPurpose: Enzalutamide after abiraterone progression is commonly used in metastatic castration-resistant prostate cancer despite a low rate of clinical benefit. Analyzing IMbassador250, a phase III trial assessing enzalutamide with or without atezolizumab after abiraterone, we hypothesized that baseline and early changes in circulating tumor DNA (ctDNA) tumor fraction (TF) may identify patients more likely to exhibit survival benefit from enzalutamide.
Experimental Design: ctDNA was quantified from plasma samples using a tissue-agnostic assay without buffy coat sequencing.
Article Synopsis
- Myoglobin (MB) expression in breast cancer is linked to better patient prognosis and its exact role in tumor growth is still not fully understood.
- Researchers used CRISPR/Cas9 to create MB-deficient breast cancer cell lines (MCF7 and SKBR3) and found that loss of MB led to increased cell survival, upregulated cell cycle proteins, and reduced apoptosis, making these cells less responsive to the chemotherapy drug doxorubicin.
- In hypoxic conditions, lacking MB promoted cell migration and invasion, while in human invasive mammary tumors, MB's presence correlated with reduced apoptosis and a more favorable prognosis, suggesting that MB has important tumor-suppressive effects in cancer cells.
Article Synopsis
- Understanding microscopic attributes in nanocomposites helps improve and speed up system designs.
- This study focuses on the binding strength between graphene oxide and cellulose, utilizing first-principles calculations combined with machine learning.
- We classify the systems by binding energies and validate our findings through theoretical X-ray photoelectron spectroscopy, ultimately offering a framework for better control of graphene oxide/cellulose interactions.