Publications by authors named "R D Harbison"
Background: Head and neck squamous cell carcinoma (HNSCC) is the 6 leading cause of cancer-related mortality, with racial disparities amplifying the challenges in treatment. Although the relationship between hybrid epithelial/mesenchymal (E/M) states and tumor progression is of interest, no studies have characterized the clinical relevance of hybrid E/M states in head and neck cancer outcomes among self-reported racial cohorts.
Methods: Given the overlap in gene expression between hybrid E/M malignant cells and cancer-associated fibroblasts, we utilized deconvolution of bulk RNA sequencing data from oral cavity and laryngeal squamous cell carcinoma tumors from The Cancer Genome Atlas.
Article Synopsis
- The study aimed to compare the long-term health-related quality of life (HRQOL) between patients who underwent Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) and those who had the traditional transcervical approach (TCA) for thyroid surgery.
- A web-based survey was conducted with patients from a tertiary referral center, evaluating their quality of life using four standardized tools, with a focus on patients who were at least six months post-surgery.
- Results showed no significant differences in overall HRQOL scores between TOETVA and TCA patients, but those in the TOETVA group reported being less self-conscious about their skin.
Objectives: To determine the association between neighborhood socioeconomic status (nSES), race and incidence rate trends of oral cavity cancer (OCC).
Materials And Methods: We used data from the SEER (Surveillance, Epidemiology, and End Results) 18 Census Tract-level SES and Rurality Database (2006-2018) database of the National Cancer Institute to create cohorts of OCC patients between 2006 and 2018. Annual incidence rates were calculated and trends in rates were estimated using joinpoints regression.
TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment.
Front Endocrinol (Lausanne)
September 2023
Article Synopsis
- The study explores a new device called hANDY-i, designed to help locate parathyroid glands during a minimally invasive thyroid surgery called transoral endoscopic thyroidectomy vestibular approach (TOETVA).
- The hANDY-i uses advanced imaging technology to provide real-time views of both normal and near-infrared fluorescence of the parathyroid glands, assisting surgeons during the procedure.
- Initial results show that this device successfully identified parathyroid glands in a cadaver and two patients, indicating potential benefits for preventing complications, but more research is needed to confirm its effectiveness in reducing postoperative issues.
Background: Surgery and/or platinum-based chemoradiation remain standard of care for patients with head and neck squamous cell carcinoma (HNSCC). While these therapies are effective in a subset of patients, a substantial proportion experience recurrence or treatment resistance. As cisplatin mediates cytotoxicity through oxidative stress while polyamines play a role in redox regulation, we posited that combining cisplatin with polyamine transport inhibitor, AMXT-1501, would increase oxidative stress and tumor cell death in HNSCC cells.
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