Challenges in diagnosing concurrent acute leukemia in an immunosuppressed patient with systemic lupus erythematosus: A case report.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by damage to organs and cells, initially mediated by tissue-binding autoantibodies and immune complexes. Lymphomas have been frequently reported, but the association of SLE with acute leukemia is rare and likely coincidental. We report a case of a 40-year-old female admitted for an etiological diagnosis of fever and dyspnea with peripheral edema.

Unveiling cyclodextrin conjugation as multidentate excipients: An exploratory journey across industries.

The discovery of branched molecules like dextrin by Schardinger in 1903 marked the inception of cyclodextrin (CD) utilization, catalyzing its journey from laboratory experimentation to widespread commercialization within the pharmaceutical industry. CD, a cyclic oligosaccharide containing glucopyranose units, acts as a versatile guest molecule, forming inclusion complexes (ICs) with various host molecules. Computational studies have become instrumental in elucidating the intricate interactions between β-CD and guest molecules, enabling the prediction of binding energy, forces, affinity, and complex stability.

An evaluation of knowledge, attitudes, practice, and associated factors regarding oxygen therapy among resident doctors in a tertiary care teaching hospital: A mixed-methods study.

Background: Despite oxygen therapy guidelines, suboptimal practices prevail among front-line resident doctors, highlighting knowledge and attitudinal barriers. Mixed-methods research can inform tailored quality improvements. This study aimed to assess the knowledge, attitudes, and practices of resident doctors regarding oxygen therapy, determine associated factors quantitatively, and explore experiences, barriers, and enablers qualitatively.

Trial by fire: The qualitative essence of interns' baptism into medical responsibility.

Background: The transition from medical student to intern represents a challenging period of professional and personal development. This study aimed to explore junior doctors' experiences navigating this critical passage.

Materials And Methods: An exploratory qualitative study was conducted on a junior intern doctor working in a tertiary care hospital, in Gujarat.

Viral and Immune Risk Factors of HIV Rebound after Interruption of Antiretroviral Therapy.

Background: Identifying risk factors for HIV rebound after treatment interruption is crucial for designing effective remission strategies.

Methods: Peripheral blood mononuclear cells from participants in the Zurich HIV Primary Infection Cohort (ZPHI, N=73) and ACTG study A5345 (N=44) were analyzed before ART interruption. We measured cell-associated HIV RNA, total HIV DNA, and proviral diversity (env gene).