Publications by authors named "R D Colucci"
Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist approved for the treatment of Crohn's disease (CD). Only limited real-life data on the long-term outcomes of CD patients treated with UST are available. This study assessed UST's long-term effectiveness and safety in a large population-based cohort of moderate to severe CD patients.
View Article and Find Full Text PDFCorrection for ' HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis' by C. Di Salvo , , 2024, , 10323-10338, https://doi.org/10.
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- VASER liposuction is a modern fat removal technique that allows for precise body shaping with less trauma to surrounding tissues, resulting in reduced pain, swelling, and recovery time compared to traditional methods.
- A study was conducted to compare complication rates in patients undergoing VASER liposuction based on their body mass index (BMI) and the quantity of fat removed.
- Findings revealed that patients with a BMI over 25 experienced complications like contusions and hematomas, while those with a BMI under 24.9 had no complications, suggesting that careful patient selection based on BMI and other factors can enhance outcomes and reduce risks.
: Growing evidence highlights the relevance of the microbiota-gut-brain axis in Alzheimer's disease (AD). AD patients display gut dysbiosis, altered intestinal barrier and enteric inflammation that, besides bowel symptoms, can contribute to brain pathology. In this context, the modulation of gut microbiota is emerging as a therapeutical option to halt or slow down central pathology.
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- This study explores how the NLRP3 inflammasome influences changes in the intestinal epithelial barrier (IEB) linked to obesity, particularly focusing on interactions between enteric glia and intestinal epithelial cells (IECs).
- Mice on a high-fat diet exhibited weight gain, compromised IEB integrity, increased glial cells, and NLRP3 inflammasome activation; however, NLRP3-deficient mice had less weight gain and better IEB integrity.
- The findings suggest that the NLRP3 inflammasome in enteric glia could be a potential target for new drugs to improve IEB integrity in obesity-related conditions.