Evaluation of electrospray transport CID for the generation of searchable libraries.

This paper reports the preliminary investigation of performance-based standard conditions that have been developed for electrospray ionization mass spectrometry. Using performance-based standard criteria, reproducible spectra can be obtained by CID in the electrospray-transport region and searched using a database created using the same performance criteria. To generate library-searchable mass spectra, the instrument was tuned to standard conditions that correspond to low, mid, and high fragmentation energies.

Comparison of the core size distribution in iron dextran complexes using Mössbauer spectroscopy and X-ray diffraction.

Mössbauer spectra of a series of iron dextran complexes in the intermediate temperature range where both sextet and doublet coexist may be used to obtain a qualitative description of the distribution of core sizes in these samples. Eight samples from five suppliers have been examined at 100 and 77 K. These differ markedly in the relative doublet contribution to the total spectral area and also in the hyperfine fields characterizing the sextets.

A Mössbauer and X-ray powder diffraction study of some ferrous hematinics.

Iron deficiency anemia is a relatively common illness that can arise from a number of different causes. Three ferrous salts are usually used in its treatment: ferrous fumarate, gluconate, and sulfate. They are administered orally and are relatively well tolerated.

The recharacterization of a polysaccharide iron complex (Niferex).

An oral hematinic marketed as "Niferex," the active component of which is a polysaccharide-iron complex (PIC), has recently been recharacterized. PIC is synthesized by the neutralization of an FeCl3 carbohydrate solution. Original characterization of this complex by Mössbauer spectroscopy and X-ray powder diffraction suggested that the iron-rich core was similar in structure to the mineral ferrihydrite.

Comparison of polysaccharide iron complexes used as iron supplements.

An oral hematinic marketed as "water soluble polysaccharide iron complex" (Vitaline Formulas) has been characterized using x-ray powder diffraction and Mössbauer spectroscopy. Another polysaccharide iron complex marketed as Niferex (Central Pharmaceuticals) has been previously studied by us and found to have a core similar to ferrihydrite, but with some long-range order of the mineral akaganéite, beta-FeOOH. The latter is seen in other ferric carbohydrate complexes synthesized by the hydrolysis of FeCl3.