Publications by authors named "R D Bair"
Article Synopsis
- Scientists studied a group of people with multiple sclerosis (MS) to find a special antibody that could help diagnose the disease.
- They found that about 10% of these patients had a unique pattern of antibodies that could appear years before they showed any symptoms of MS.
- This discovery might help doctors identify people at high risk for MS earlier, even before the disease fully develops.
Autoimmunity is characterized by loss of tolerance to tissue-specific as well as systemic antigens, resulting in complex autoantibody landscapes. Here, we introduce and extensively validate the performance characteristics of a murine proteome-wide library for phage display immunoprecipitation and sequencing (PhIP-seq) in profiling mouse autoantibodies. This library was validated using 7 genetically distinct mouse lines across a spectrum of autoreactivity.
View Article and Find Full Text PDFDeveloping advanced onsite wastewater treatment systems (OWTS) requires accurate and consistent water quality monitoring to evaluate treatment efficiency and ensure regulatory compliance. However, off-line parameters such as chemical oxygen demand (COD), total suspended solids (TSS), and () require sample collection and time-consuming laboratory analyses that do not provide real-time information of system performance or component failure. While real-time COD analyzers have emerged in recent years, they are not economically viable for onsite systems due to cost and chemical consumables.
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- Achieving safe sanitation in rural or densely populated areas can be challenging due to the high costs and space needed for traditional sewer systems; nonsewered sanitation (NSS) options, like the NEWgenerator, offer a potential solution with effective wastewater treatment capabilities.
- The NEWgenerator combines anaerobic processes and nutrient recovery technology, providing adequate waste treatment for over 100 users, but its overall environmental sustainability and financial viability require further analysis.
- Cost analysis shows that while using grid electricity results in lower upfront costs and higher greenhouse gas emissions, switching to solar energy increases costs slightly but significantly reduces GHG emissions; locations such as China and India offer promising cost reductions for
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster of PwMS that share an autoantibody signature against a common motif that has similarity with many human pathogens.
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