Publications by authors named "R D AZULAY"
Background/objectives: Approximately 25% of the world's population and more than 60% of patients with type 2 diabetes (T2D) have metabolic-dysfunction-associated steatotic liver disease (MASLD). The association between these pathologies is an important cause of morbidity and mortality in Brazil and worldwide due to the high frequency of advanced fibrosis and cirrhosis. The objective of this study was to determine the epidemiologic and clinical-laboratory profile of patients with T2D and MASLD treated at an endocrinology reference service in a state in northeastern Brazil, and to investigate the association of liver fibrosis with anthropometric and laboratory measurements.
View Article and Find Full Text PDFRelationship Between C-Peptide Levels, Clinical Features, and Serum Data in a Brazilian Type 1 Diabetes Population with Large Variations in Genomic Ancestry.
Int J Mol Sci
October 2024
Article Synopsis
- - Type 1 diabetes (T1D) is a chronic condition where the immune system attacks beta cells in the pancreas that produce insulin; C-peptide, released alongside insulin, is a helpful marker for evaluating pancreatic function due to its longer lifespan in the body.
- - A study involving 95 T1D patients focused on the levels of C-peptide and its relationship with factors like age, revealing that nearly 30% had some remaining insulin secretion, primarily linked to their age at diagnosis.
- - No significant differences were found in metabolic control or microvascular complications based on C-peptide levels, and it was noted that ancestry did not affect residual C-peptide function; future research should explore additional factors like HLA and pancreatic auto
The expression of and family genes in pituitary adenomas: clinical correlations and postsurgical outcomes.
Front Endocrinol (Lausanne)
October 2024
Introduction: Pituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely understood at the molecular level. BAK1 and BAX proteins play fundamental roles in apoptosis and seem to interact with VDAC proteins, whose expressions have been markedly altered in cancer, impacting their prognosis.
View Article and Find Full Text PDFClinical factors associated with salivary flow rate in adults with acromegaly.
Oral Surg Oral Med Oral Pathol Oral Radiol
December 2024
Objective: To investigate the stimulated salivary flow (SSF) and unstimulated salivary flow (USF) in adults with acromegaly and to identify possible clinical factors associated with salivary flow.
Study Design: A case-control study was conducted with a group composed of adults diagnosed with acromegaly (n = 29, mean age = 50.2 years) and a control group (n = 29, mean age = 54.
Interactions between multiple genes and environmental factors could be related to the pathogenesis of type 1 diabetes (T1D). The Brazilian population results from different historical miscegenation events, resulting in a highly diverse genetic pool. This study aimed to analyze the mtDNA of patients with T1D and to investigate whether there is a relationship between maternal ancestry, self-reported color and the presence of T1D.
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