The vegetation of Holocene coastal dunes of the Cape south coast, South Africa.

The vegetation of calcareous coastal dunes of Holocene age along the south coast of South Africa's Cape Floristic Region is poorly described. This vegetation comprises a mosaic of communities associated with two biomes, Fynbos and Subtropical Thicket. Previously, expert knowledge rather than quantitative floristic analysis has been used to identify and delimit vegetation units.

A multi-stem cell basis for craniosynostosis and calvarial mineralization.

Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis reflect the interaction of two separate stem cell lineages; a previously identified cathepsin K (CTSK) lineage CSC (CTSK CSC) and a separate discoidin domain-containing receptor 2 (DDR2) lineage stem cell (DDR2 CSC) that we identified in this study.

Fossil pollen resolves origin of the South African Proteaceae as transcontinental not transoceanic.

Background And Aims: The prevailing view from the areocladogenesis of molecular phylogenies is that the iconic South African Cape Proteaceae (subfamily Proteoideae) arrived from Australia across the Indian Ocean during the Late Cretaceous (100-65 million years ago, Ma). Since fossil pollen indicates that the family probably arose in North-West Africa during the Early Cretaceous, an alternative view is that it migrated to the Cape from North-West-Central Africa. The plan therefore was to collate fossil pollen records throughout Africa to determine if they are consistent with an African (para-autochthonous) origin for the Cape Proteaceae, and to seek further support from other palaeo-disciplines.

Control of craniofacial development by the collagen receptor, discoidin domain receptor 2.

Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in the discoidin domain receptor 2 gene (), which encodes a non-integrin collagen receptor, are associated with human craniofacial abnormalities, such as midface hypoplasia and open fontanels.

Canopy plant composition and structure of Cape subtropical dune thicket are predicted by the levels of fire exposure.

Background: The subtropical dune thicket (hereafter "dune thicket") of the Cape Floristic Region experiences a wide range of fire exposure throughout the landscape, unlike other dry rainforest formations that rarely experience fire. We sought to determine how fire exposure influences species composition and the architectural composition of dune thicket.

Methods: We used multivariate analysis and diversity indices based on cover abundance of species to describe the species composition, architectural guild composition and structure of dune thicket sites subject to different levels of fire exposure, namely low (fire return interval of >100 years), moderate (fire return interval of 50-100 years), and high (fire return interval of 10-50 years).