Publications by authors named "R Cowell"
The (in)dependence of single-cell data inferences on model constructs.
Forensic Sci Int Genet
January 2025
Recent developments in single-cell analysis have revolutionized basic research and have garnered the attention of the forensic domain. Though single-cell analysis is not new to forensics, the ways in which these data can be generated and interpreted are. Modern interpretation strategies report likelihood ratios that rely on a model of the world that is a simplification of it.
View Article and Find Full Text PDFThe endosomal sorting complexes required for transport (ESCRT) pathway is composed of a series of protein complexes that are essential for sorting cargo through the endosome. In neurons, the ESCRT pathway is a key mediator of many cellular pathways that regulate neuronal morphogenesis as well as synaptic growth and function. The ESCRT-0 complex, consisting of HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule), acts as a gate keeper to this pathway, ultimately determining the fate of the endosomal cargo.
View Article and Find Full Text PDFArticle Synopsis
- A 50-something woman experienced an atraumatic splenic rupture linked to Epstein-Barr virus (EBV) after initially presenting with pneumonia and sepsis.
- CT scans showed the rupture and a large perisplenic hematoma, and lab tests confirmed EBV infection.
- Due to her frailty, the treatment involved fluoroscopy-guided splenic artery embolization, emphasizing the uncommon risk of splenic rupture from EBV, which can occur without typical mononucleosis symptoms.
Article Synopsis
- Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) feature harmful protein aggregates called Lewy Pathology, notably in the basolateral amygdala, which affects cognition and emotional processing.
- Research using C57BL/6 J mice injected with α-syn pre-formed fibrils (PFFs) indicates that while synapse loss is minimal, the structure of excitatory synapses in the amygdala changes significantly post-aggregation, increasing their size and volume.
- Additionally, findings suggest that pathological α-syn influences synaptic functioning by altering distances between synaptic vesicles, indicating a link between protein aggregation and synaptic transmission issues.