Publications by authors named "R Corre"
Article Synopsis
- The study investigates the effectiveness of combined treatment with anti-PD-1 (nivolumab) and anti-CTLA-4 (ipilimumab) antibodies compared to standard platinum-based chemotherapy in older patients with advanced non-small-cell lung cancer (NSCLC).
- It focuses specifically on patients aged 70 years or older or those with an ECOG performance status of 2, as there is limited data on this demographic.
- The trial is a phase 3 randomized controlled study conducted across 30 sites in France, aiming to evaluate overall survival, progression-free survival, and safety of the treatments in the intended patient population.
Article Synopsis
- Venous thromboembolism is linked to endothelial cell activation, inflammation, and the release of extracellular RNA (eRNA), with TLR3 potentially serving as the receptor for eRNA in this process.
- Experiments involving mice with and without TLR3 showed that eRNA influenced thrombus size and formation, with treatments affecting signaling pathways and neutrophil recruitment.
- Overall, the study highlights the role of TLR3 and eRNA in promoting venous thromboembolism, indicating their potential as therapeutic targets for managing this condition.
Article Synopsis
- Lung cancer is a leading cause of cancer-related deaths, necessitating advanced preclinical models to explore new treatments based on tumor genetics.
- Researchers developed and characterized cell lines and mouse models for non-small cell lung cancer (NSCLC) to monitor tumor growth and treatment response effectively.
- The study found that combining osimertinib and bevacizumab improves treatment outcomes for EGFR-mutated tumors, while adding afatinib helps inhibit tumor growth during treatment resistance, demonstrating the models’ utility for testing new therapies and understanding resistance mechanisms.
Estradiol (E2) is a major hormone-controlling folliculogenesis whose dysfunction may participate in polycystic ovary syndrome (PCOS) infertility. To determine whether both the concentration and action of E2 could be impaired in non-hyperandrogenic overweight PCOS women, we isolated granulosa cells (GCs) and follicular fluid (FF) from follicles of women undergoing ovarian stimulation (27 with PCOS, and 54 without PCOS). An analysis of the transcript abundance of 16 genes in GCs showed that androgen and progesterone receptor expressions were significantly increased in GCs of PCOS (by 2.
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