Publications by authors named "R Corbo"
Article Synopsis
- - Medullary thyroid carcinoma (MTC) is a rare cancer linked to mutations in the RET proto-oncogene, with specific treatments available for cases involving these mutations.
- - Selective RET inhibitors have been approved for clinical use, showing effectiveness with low toxicity, but treatment options are limited for patients with RET-negative MTC.
- - Peptide receptor radionuclide therapy (PRRT) is being explored as a potential option for treatment, although its effectiveness compared to current therapies is still being studied.
Radioiodine treatment in female survivors of pediatric differentiated thyroid carcinoma does not affect future pregnancy rates.
Arch Endocrinol Metab
November 2024
Objective: Patients with pediatric differentiated thyroid carcinoma (DTC) treated with radioiodine (RAI) therapy may experience long-term side effects, such as gonadal dysfunction. Therefore, it is crucial to understand the impact of this therapy on ovarian reserve and future pregnancy rates.
Subjects And Methods: Retrospective analysis of 64 female DTC survivors of childbearing age to assess the risk of infertility due to RAI performed before the age of 19 years.
Background: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by an expanded GAA repeat in the first intron of the FXN gene.
Objective: The aim of this study was to analyze leukocyte telomeres length (LTL) in FRDA to verify the possible relationships between LTL and disease progression. We investigated LTL in a cohort of FRDA biallelic patients (n = 61), heterozygous (n = 29), and age-matched healthy subjects (n = 87).
External beam radiation therapy for recurrent or residual thyroid cancer: What is the best treatment time and the best candidate for long-term local disease control?
Head Neck
June 2024
Introduction: Cervical disease control might be challenging in advanced thyroid cancer (DTC). Indications for cervical external beam radiation therapy (EBRT) are controversial.
Purpose: To identify clinical and molecular factors associated with control of cervical disease with EBRT.
Stimulated thyroglobulin and diagnostic 131-iodine whole-body scan as a predictor of distant metastasis and association with response to treatment in pediatric thyroid cancer patients.
Endocrine
June 2024
Introduction: Differentiated thyroid carcinoma (DTC) is a rare oncological disease in the pediatric population, presenting with a more aggressive form. Stimulated thyroglobulin (sTg) and the 131-iodine whole-body scans (WBSs) are known adult markers related to the presence of distant metastasis. Little is known about their roles in the pediatric population.
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