Publications by authors named "R Colonna"
Behaviour change interventions delivered via smartphones have the potential to reduce youth cannabis use and driving under the influence of cannabis (DUIC). Countless smartphone applications (either downloadable or web-based) are available to help reduce substance use and impaired driving. However, most are developed without evidence-based content and theory, and many have poor user engagement.
View Article and Find Full Text PDFTo fulfill their function, pancreatic beta cells require precise nutrient-sensing mechanisms that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here, we show that TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability.
View Article and Find Full Text PDFArticle Synopsis
- Mutant Z alpha-1 antitrypsin (ATZ) builds up in liver globules, leading to a type of liver disease, prompting the need for effective treatment strategies.
- The study highlights that activating TRPML1, a lysosomal calcium channel, can help reduce these ATZ globules and liver fibrosis in specific mouse models.
- This approach works by enhancing lysosomal exocytosis without increasing autophagy, suggesting a new potential treatment for liver diseases caused by protein buildup, including those linked to ATZ.
Introduction: Brief interventions delivered using mobile technologies have become popular to reduce youth alcohol use, however, few have been applied to cannabis use and driving under the influence of cannabis (DUIC). This Delphi study sought to create and compare consensus among a panel of experts (potential intervention developers) and a panel of youth (intervention audience) on the characteristics to prioritize in a youth DUIC mobile-based brief intervention.
Methods: A two-round two-panel Delphi study was conducted among 26 professionals with expertise in youth substance use and impaired driving and 20 youth who use cannabis.