Publications by authors named "R Collis"
Background: The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri-operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and improved haemovigilance, have become apparent over the past decade.
View Article and Find Full Text PDFUnderstanding the composition of complex Escherichia coli populations from the environment is necessary for identifying strategies to reduce the impacts of fecal contamination and protect public health. Metabarcoding targeting the hypervariable gene gnd was used to reveal the complex population diversity of E. coli and phenotypically indistinct Escherichia species in water, soil, sediment, aquatic biofilm, and fecal samples from native forest and pastoral sites.
View Article and Find Full Text PDFAntimicrobial resistance is a global public and animal health concern. Antimicrobial resistance genes (ARGs) have been detected in dairy farm environments globally; however, few longitudinal studies have utilized shotgun metagenomics for ARG surveillance in pasture-based systems. This 15-month study aimed to undertake a baseline survey using shotgun metagenomics to assess the relative abundance and diversity of ARGs in two pasture-based dairy farm environments in New Zealand with different management practices.
View Article and Find Full Text PDFArticle Synopsis
- The Obstetric Bleeding Study UK (OBS UK) is a randomized controlled trial aimed at addressing postpartum hemorrhage, initially developed in Wales, which has noted improved maternal outcomes but faces limitations in generalizability due to demographic homogeneity in the Welsh sample.* -
- To enhance the diversity and inclusivity of the trial, maternity units across the UK were selected based on their representation of various ethnic and socioeconomic profiles, with a focus on ensuring results are applicable to a broader population.* -
- An interactive dashboard was created using census data to visualize and compare the demographics of each participating maternity unit, confirming that the trial sites reflect the wider UK's ethnic and socioeconomic diversity, despite some inconsistencies in data availability across different locations.*
Article Synopsis
- This study analyzes the proteomic differences within specific regions of the bovine heart, aiming to understand variations beyond just whole cardiac chambers.
- Researchers identified three distinct proteomes based on samples taken from different heart sections, revealing relationships between proteomic variations and cardiac regions like the outer walls of ventricles and the septum.
- Findings showed differences in protein abundances related to energy metabolism, and a specific disease-related protein was linked predominantly to the outer wall of the left ventricle, emphasizing that proteomic diversity doesn't always align with anatomical structures.