Towards H&E Referenced Multiplex Immunofluorescence Interpretation: Spatial Co-localization, Cell Feature Validation, and Virtual H&E Generation.

Multiplexed Immunofluorescence (MxIF) enables detailed immune cell phenotyping, providing critical insights into cell behavior within the tumor immune microenvironment (TIME). However, signal integrity can be compromised due to the complex cyclic staining processes inherent to MxIF. Hematoxylin and Eosin (H&E) staining, on the other hand, offers complementary information through its depiction of cell morphology and texture patterns and is often visually cross-referenced with MxIF in clinical settings.

Cell site analysis; testing understanding via internal consistency checks.

This paper is aimed at Cell Site Analysis Expert Witnesses. Ground Truth Data (GTD) are essential to validation exercises, but in the UK access to practitioner-generated Call Data Records (the traces considered by Cell Site Analysis experts) are restricted, reducing opportunities for practitioners to test their understanding against real-world data. This paper outlines methods by which casework material might be used to potentially detect issues within understanding of uncertainties (and therefore improve the reliability of analyses) by reviewing the properties of casework material in parallel with the casework assessment being conducted.

Endometrioid adenocarcinoma of the colon arising from rare malignant transformation of extra-gonadal endometrioma.

Background: Endometriosis is a common condition with a rare malignant potential. We report a case of a patient with a colon mass who underwent surgery for malignant endometriosis associated cancer.Case: A 70-year-old woman with a pelvic mass who was lost to follow-up for 6 years represented with an enlarging pelvic mass involving the sigmoid colon.

Factors Associated With Outdoor Frequency Among U.S. Community-Dwelling Medicare Beneficiaries: A Cross-Sectional Study.

Purpose: Despite the benefits of outdoor activity in older adults, a paucity of research explores factors associated with the frequency of older adults going outdoors. The aim of the current study was to investigate if factors of cognitive status, physical performance, and neighborhood characteristics were associated with outdoor frequency among older adults.

Method: This cross-sectional study used National Health and Aging Trends Study data to characterize outdoor frequency among Medicare beneficiaries by participant demographics, health, and neighborhood characteristics, and estimated relationships between participant factors and outdoor frequency.

Differential Effects of Alcohol Policies Across Race/Ethnicity and Socioeconomic Status.

Purpose: Sociocultural characteristics, including race/ethnicity and socioeconomic status (SES), may affect individuals' attitudes and norms regarding alcohol use and treatment as well as their access to emerging health knowledge, innovative technologies, and general resources for improving health. As a result of these differences, as well as social determinants of health such as stigma and uneven enforcement, alcohol policies may not benefit all population subgroups equally. This review addresses research conducted within the last decade that examined differential effects of alcohol policies on alcohol consumption, alcohol harm, and alcohol treatment admissions across racial/ethnic and socioeconomic groups.