Publications by authors named "R Cleper"
Background: X-linked hypophosphatemic rickets (XLH) is associated with uninhibited FGF23 activity, which leads to phosphaturia, hypophosphatemia and depressed active vitamin D (1,25OH2D) levels. Conventional treatment with phosphate supplements and vitamin D analogs may lead to hypercalciuria (HC), nephrocalcinosis (NC) and hyperparathyroidism. We investigated the effects of burosumab treatment, an anti-FGF23 monoclonal antibody recently approved for XLH, on these complications.
View Article and Find Full Text PDFObjectives: to assess the association between delivery mode and causative pathogens of infants with urinary tract infections.
Materials And Methods: We conducted a retrospective analysis of the medical records of neonates delivered in a tertiary academic pediatric hospital and diagnosed with urinary tract infections between January 1,2013 and December 31,2017. Excluded were newborns with urinary tract infections post-urological procedures or neurogenic bladders.
Article Synopsis
- X-linked hypophosphatemia (XLH) is a genetic condition caused by a mutation affecting the regulation of FGF23, which can lead to cardiovascular issues, but the extent of these effects in XLH patients is unclear.
- A study involving 13 pediatric XLH patients evaluated the impact of a 2-year treatment with burosumab, measuring various health metrics including cardiovascular health through blood pressure and echocardiograms.
- Results showed significant improvements in linear growth, a decrease in rates of overweight/obesity, and a reduction in elevated blood pressure, with no adverse cardiac effects noted during the treatment period.
Unlabelled: To assess the long-term efficacy of burosumab for pediatric patients with X-linked hypophosphatemia, focusing on linear growth. This multi-center retrospective study included 35 pediatric patients who began treatment with burosumab between January 2018 and January 2021. We collected clinical data, anthropometric measurements, laboratory results, and Rickets Severity Score (RSS), from 2 years prior to treatment initiation and up to 4 years after.
View Article and Find Full Text PDFBackground: Exstrophy-epispadias complex (EEC) is a complex malformation of the lower abdominal wall, bladder, and pelvic floor, which necessitates multiple successive reconstruction procedures. Surgical and infectious complications are frequent. Our aim was to evaluate kidney function in these patients.
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