Pharmacokinetic Comparison of Subcutaneous and Intravenous Nadroparin Administration for Thromboprophylaxis in Critically Ill Patients on Vasopressors.

Introduction: Critically ill patients are exposed to a high risk of developing thromboembolism. Moreover, standard prophylaxis with subcutaneous (SC) heparin is less efficient in patients requiring vasopressors. The aim is a comparison of pharmacokinetics between SC and intravenous (IV) applied nadroparin.

Comparing micellar, hemolytic, and antibacterial properties of di- and tricarboxyl dendritic amphiphiles.

Homologous dicarboxyl dendritic amphiphiles-RCONHC(CH(3))(CH(2)CH(2)COOH)(2), 4(n); and ROCONHC(CH(3))(CH(2)CH(2)COOH)(2), 5(n), where R=n-C(n)H(2)(n)(+1) and n=13-22 carbon atoms-were synthesized. Critical micelle concentrations (CMCs) in aqueous triethanolamine solutions and at pH 7.4 were measured along with hemolytic activity (effective concentrations, EC(10)) in phosphate-buffered saline (PBS).

[Augmentation of decompressive craniectomy using COM 30 bandage in the treatment of refractory intracranial hypertension].

Authors present case-report of 29-year old man with acute subdural hematoma and contusions in right basal frontotemporal area. Despite adequate conservative treatment and surgical therapy (hematoma evacuation and decompressive craniectomy) uncontrollable intracranial hypertension occurred 4th postoperative day. Situation has been effectively solved by resection of hemorrhagic temporal muscle together with duroplasty (fascia lata) and skin plastics using combined dressing fabric COM 30.