Publications by authors named "R Christopher Harmon"
Head and neck squamous cell carcinoma (HNSCC) is diagnosed in more than 71,000 patients each year in the United States, with nearly 16,000 associated deaths. One significant hurdle in the treatment of HNSCC is acquired and intrinsic resistance to existing therapeutic agents. Over the past several decades, the University of Wisconsin has formed a multidisciplinary team to move basic scientific discovery along the translational spectrum to impact the lives of HNSCC patients.
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- * Researchers found that NP B cells expressing the extrafollicular marker EBI2 had a higher propensity for autoantibody production and that NP ASCs were more common than those in tonsils.
- * Analysis showed significant differences in the composition and molecular characteristics of B cells, indicating that NP EBI2+ ASCs produce more total and anti-dsDNA IgG and exhibit traits of mature plasma cells.
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- * Genetic forms of these disorders, like Darier and Hailey-Hailey diseases, stem from mutations affecting calcium pumps but lack a clear connection between these mutations and the breakdown of cell adhesion.
- * The article reviews existing knowledge about these conditions and emphasizes research gaps, aiming to stimulate investigations that could lead to new treatments for affected patients suffering from chronic skin issues.
Higher prevalence of autism spectrum disorder (ASD) diagnosis and associated traits has been observed among transgender and gender diverse (TGD) youth, and the number of TGD youth requesting evaluation for autism is growing. This study explored the demographic and clinical profiles of TGD youth evaluated in a specialty autism clinic. Retrospective autism evaluation results for 41 TGD youth aged 5-18 years and 67 cisgender-matched controls were included in the study.
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