Aqueous Photolysis of Water-Soluble Brown Carbon from Simulated Prescribed and Wildfire Biomass Burning.

This work, as part of the Georgia Wildland fire Simulation Experiment (G-WISE) campaign, explores the aqueous photolysis of water-soluble brown carbon (W-BrC) in biomass burning aerosols from the combustion of fuel beds collected from three distinct ecoregions in Georgia: Piedmont, Coastal Plain, and Blue Ridge. Burns were conducted under conditions representative of wildfires, which are common unplanned occurrences in Southeastern forests (low fuel moisture content), and prescribed fires, which are commonly used in forest management (higher fuel moisture content). Upon exposure to radiation from UV lamps equivalent to approximately 5 h in the atmosphere, the absorption spectra of all six samples exhibited up to 40% photobleaching in the UV range (280-400 nm) and as much as 30% photo-enhancement in the visible range (400-500 nm).

Optical Properties of Biomass Burning Aerosols from Simulated Wildfires and Prescribed Fires with Representative Fuel Beds from the Southeast United States.

We report measurements of the absorption Ångström exponent (AAE) and single scattering albedo (SSA) of biomass burning aerosol from the combustion of fuel beds representing three eco-regions of the Southeast U.S. (Piedmont, Coastal Plain, and Blue Ridge Mountains) with moisture content representative of wildfires and prescribed fires.

Brown Carbon Emissions from Biomass Burning under Simulated Wildfire and Prescribed-Fire Conditions.

We investigated the light-absorption properties of brown carbon (BrC) as part of the Georgia Wildland-Fire Simulation Experiment. We constructed fuel beds representative of three ecoregions in the Southeastern U.S.

Population Pharmacodynamic Dose-Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate.

Background: Sodium zirconium cyclosilicate (SZC) is an approved oral treatment for hyperkalemia that selectively binds potassium (K) in the gastrointestinal tract and removes K from the body through increased fecal excretion. Here, we describe the population pharmacodynamic (PopPD) response of serum K concentration in patients with hyperkalemia who are treated with SZC, estimate the impact of patients' intrinsic and extrinsic factors, and compare predicted serum K responses between 5 g alternate daily (QOD) and 2.5 g once daily (QD) maintenance doses.

Potassium homeostasis and therapeutic intervention with sodium zirconium cyclosilicate: A model-informed drug development case study.

Potassium (K ) is the main intracellular cation in the body. Elevated K levels (hyperkalemia) increase the risk of life-threatening arrhythmias and sudden cardiac death. However, the details of K homeostasis and the effects of orally administered K binders, such as sodium zirconium cyclosilicate (SZC), on K redistribution and excretion in patients remain incompletely understood.