Publications by authors named "R Choquet"
Article Synopsis
- The study focuses on improving the quantitative validation of theoretical models in infectious disease dynamics, particularly for a polymorphic viral population.
- It details an experiment involving a temperate bacteriophage to assess how epidemiological dynamics affect virus transmission and virulence.
- The findings highlight the importance of directly modeling infected bacterial cells to enhance fit with experimental data, and introduce estimations for key traits of the viral strains, ultimately enriching our understanding of the phage's evolutionary epidemiology.
Background: Demonstration of trial emulation ability to benchmark randomised controlled trials (RCTs) from real-world data (RWD) is required to increase confidence in the use of routinely collected data for decision making in oncology.
Methods: To assess the frequency with which emulation findings align with RCTs regarding effect size on overall survival (OS) in metastatic breast cancer (MBC), 8 of 13 pre-selected pivotal RCTs in MBC were emulated using data from 32,598 patients enrolled in the French ESME-MBC cohort between January 1, 2008 and December 31, 2021. Adjustment methods and confounders were selected a priori for each emulation; stabilized weight was the reference method to mitigate confounding.
Background: Real-world evidence (RWE) can reinforce clinical trial evidence in health technology assessment (HTA).
Objectives: Review HTA bodies' (HTAbs) requirements for RWE, real uses, and acceptance across seven countries (Brazil, Canada, France, Germany, Italy, Spain, and the United Kingdom) and outline recommendations that may improve acceptance of RWE in efficacy/effectiveness assessments and appraisals processes.
Methods: RWE requirements were summarized based on HTAbs' guidelines.
Changes in the risk of exposure to infectious disease agents can be tracked through variations in antibody prevalence in vertebrate host populations. However, information on the temporal dynamics of the immune status of individuals is critical. If antibody levels persist a long time after exposure to an infectious agent, they could enable the efficient detection of the past circulation of the agent; if they persist only a short time, they could provide snap shots of recent exposure of sampled hosts.
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- * A study using GPS tracking of 31 adult griffon vultures in France in 2022 found changes in movement patterns, revealing that infected vultures showed increased immobility at their nests, averaging 5.6 days, and 3 vultures died during the study.
- * These findings suggest that the immobility of infected vultures may help reduce virus transmission, highlighting a concerning vulnerability in endangered vulture species if they contract the virus.