Climatic forcing of the Southern Ocean deep-sea ecosystem.

The deep-time development of the Southern Ocean's deep-sea ecosystem remains poorly understood, despite being a key region in global ecological, climatological, and oceanographic systems, where deep water forms and biodiversity is unexpectedly high. Here, we present an ∼500,000-year fossil record of the deep-sea Southern Ocean ecosystem in the subantarctic zone. The results indicate that changes in surface productivity and the resulting food supply to the deep sea, driven by eolian dust input and iron fertilization, along with changes in bottom-water temperature influenced by deep-water circulation, have controlled the deep-sea ecosystem in the Southern Ocean on orbital (10-10 years) timescales following the Mid-Brunhes event (MBE), a major climatic transition ∼430,000 years ago.

Is the YES/NO classification accurate in screening scapular dyskinesis in asymptomatic individuals? - A novel validation study utilizing surface electromyography as a surrogate measure in identifying movement asymmetries.

Background: Scapular dyskinesis is a known risk factor for shoulder pain, making it important to screen for prevention. Physical therapists screen scapular dyskinesis by visually comparing asymmetries in scapular movement during overhead reach using the Scapular Dyskinesis Test Yes/No classification (Y/N). Although scapular kinematics has been used to quantify scapular dyskinesis, current measurement techniques are inaccurate.

Intravascular lithotripsy in infra-popliteal peripheral artery disease.

Chronic limb-threatening ischemia (CLTI) carries a significant risk of limb loss and thus demands urgent attention. Calcified atherosclerotic disease affecting the infra-popliteal (IP) arteries poses a formidable challenge for effective revascularization due to the narrow vessel diameter and the common presence of extensively calcified, long occlusive lesions. Intravascular lithotripsy (IVL) is an endovascular treatment that induces microfractures in the medial calcifications of blood vessels, thereby facilitating the clearance of calcified obstructive arterial lesions.

Associations of optic nerve head morphology and peripapillary retinal nerve fibre layer thickness with myopic severity and treatment in children.

Purpose: This study aimed to investigate the longitudinal associations between myopic optic disc features and optical coherence tomography (OCT) measurements of peripapillary retinal nerve fibre layer (RNFL) thickness in young myopic children in Singapore.

Methods: A prospective, single-site cohort study was conducted, involving children aged 7-16 years who participated in the PROM-Kids clinical cohort study from 2019 to 2022. Participants underwent annual assessments, including cycloplegic refraction, axial length measurements, fundus photography, and OCT imaging, with ocular magnification correction.